The year is 30 BC. A messenger delivers word to Queen Cleopatra that her beloved husband, Antony, has died. Desperate to save her kingdom and resurrect her husband, Cleopatra summons the most fearsome warrior goddess, Sekhmet, and against the warnings of her scholars she strikes a mortal bargain. In exchange for Antony's soul, Cleopatra is transformed into a vampiric creature with superhuman strength and an insatiable hunger for human blood. Clashing against witches and monsters, gods and warriors, Cleopatra journeys from the tombs of Egypt to the great amphitheaters of Rome to the ancient underworld-where she will meet her love once again, and where the battle between man and beast will determine the fate of the world.