A Boeing 767 arrives at JFK. All lights are out. All communication channels have gone quiet. Crews on the ground are lost for answers, but an alert goes out to the CDC. Dr. Ephraim Goodweather, head of their Canary project, a rapid-response team that investigates biological threats, gets the call and boards the plane. What he finds makes his blood run cold.
So begins a battle of mammoth proportions as the vampiric virus that has infected New York begins to spill out into the streets. Dr. Ephraim must now find a way to stop the contagion and save his city.